Pertussis (whooping cough) and travelInformation about pertussis and the UK vaccination regime
- Routine pertussis vaccine in the UK
- Adults and children aged 10 years and over
- Vaccine recommendation for pregnant women
- Pertussis vaccine schedule in UK
Pertussis, or whooping cough, is a bacterial infection spread from person to person by the respiratory route.
The disease is present worldwide and despite sustained high vaccine coverage, several countries have seen a resurgence of whooping cough in recent years.
Infants under 6 months are at highest risk of severe complications and death from whooping cough.
Pertussis vaccination for children under 10 years and pregnant women is currently recommended as part of the routine schedule.
Pertussis vaccination is not recommended in the UK for those over 10 years old, including those visiting newborns abroad.
Additional ways to protect young infants from respiratory illness include good hand and cough hygiene and avoiding close contact with those known to be infected.
Pertussis, also known as whooping cough, is a highly infectious disease caused by the bacterium Bordetella pertussis. It is usually transmitted via the respiratory route and starts with non-specific catarrhal (‘common cold’) symptoms. Typically, an intermittent uncontrollable cough then develops, causing spasms. Coughing fits, may end with an inspiratory whoop and vomiting. Young infants do not always develop a ‘whoop’ following the coughing spasms but may instead have trouble breathing or even stop breathing for a short time.
Symptoms are worse at night and the illness can last for two to three months. Infants under six months of age are at highest risk of severe complications and death from pertussis. Milder symptoms may be observed in older children and adults who have previously been vaccinated.
Pertussis occurs worldwide and in recent years some countries with longstanding vaccine programmes have reported resurgences in disease, despite sustained high vaccine coverage . There are likely to be several factors that have affected this, including changes in testing and reporting, but in a small number of countries including the UK and United States a true increase appears to have occurred. In the UK, a pertussis-containing vaccine has been routinely offered since the 1950s. Since 1992, coverage has been consistently 92 percent or higher by the second birthday .
Routine pertussis vaccine in the UK
The main aim of the UK vaccination schedule is to reduce the risk of severe pertussis in infancy. The primary UK immunisation schedule consists of three doses of an acellular pertussis-containing vaccine at eight, twelve and sixteen weeks of age. A reinforcing dose should be administered at around three years and four months of age .
For children who have not completed a primary vaccination course or where there is an unreliable history of previous immunisation, UK Health Security Agency (formerly Public Health England) recommendations should be followed .
Adults and children aged 10 years and over
Pertussis vaccination is not routinely recommended for those aged 10 years and over, apart from pregnant women or as part of outbreak control .
A pertussis-containing vaccine can be considered as a post exposure measure for those aged more than 10 years old who have had close contact with suspected or confirmed cases of pertussis, based on the criteria set out in the guidelines for the public health management of pertussis, produced by UKHSA .
Vaccine recommendation for pregnant women
Following an increase in pertussis activity in England and Wales from October 2011 and into 2012, a national pertussis outbreak was declared. In September 2012, in response to the high number of infant cases and deaths, the Department of Health launched a pertussis vaccination programme for pregnant women .
The aim of the programme is to boost immunity in the mother during pregnancy to optimise transfer of antibodies from mother to unborn baby and thereby protect the infant from birth until they reach the age of routine immunisations (8 weeks) . The programme has been shown to be highly effective and the risk of pertussis in babies born to mothers vaccinated at least one week before delivery was reduced by around 90 percent . Vaccine effectiveness against infant deaths after maternal vaccination was estimated at 95 percent .
In June 2019 the Joint Committee on Vaccination and Immunisation recommended the maternal pertussis vaccination programme should continue as routine .
A pertussis-containing vaccine is recommended for pregnant women ideally between 20 weeks (after their foetal anomaly scan) and 32 weeks gestation (although can be given from as early as 16 weeks gestation). Women may still be immunised after week 32 of pregnancy until delivery but this may not offer as high a level of passive protection to the baby [2, 5].
A large UK study which considered the safety of maternal pertussis vaccination did not find any safety concerns .
Pertussis vaccine schedule in UK
|Vaccine||Schedule and age range|
|Infanrix hexa (DtaP/IPV/Hib/HepB) the 6-in-1 vaccine: diphtheria, tetanus, pertussis, polio, Haemophilus influenza type b and hepatitis B||Three dose schedule: given at 8, 12 and 16 weeks of age|
|Boostrix-IPV or Repevax (dTaP/IPV) the 4-in-1 vaccine: diphtheria, tetanus, pertussis and polio||Single pre-school booster dose: given at 3 years, 4 months old or soon after|
|Boostrix-IPV or Repevax (dTaP/IPV) diphtheria, tetanus, pertussis and polio||Single booster dose: offered to pregnant women (ideally between 20-32 weeks)|
Pertussis vaccine and overseas travel
The travel consultation is an ideal opportunity to ensure that all have completed the routine UK immunisation schedule.
Travellers over the age of 10 years are not routinely offered pertussis vaccination, even those who have an incomplete vaccine history or have no record of having received a pertussis containing vaccine .
In response to large outbreaks of pertussis, several countries outside the UK have recommended pertussis vaccination for adults, family, and close contacts of newborns (cocooning) as a strategy to prevent severe pertussis in newborns . However, maternal vaccination during pregnancy is thought to be more effective and favourable than cocooning . Vaccination of adults, family and close contacts visiting newborns overseas is not recommended for travellers from the UK.
Many countries offer pertussis vaccination during pregnancy . Travellers planning to visit friends and relatives who are pregnant or recently delivered can be advised to check the pertussis vaccination status of the mother before visiting.
Infants who have completed their primary schedule are well protected from pertussis. Additional measures that can be taken to protect children less than 12 months of age from respiratory illness include:
- good hand hygiene.
- avoiding close contact with persons known to be infected and those with a respiratory or coughing illness.
- ensuring individuals cover their nose and mouth when coughing or sneezing and promptly dispose of used tissues hygienically.
In the UK, pertussis vaccine (on the NHS) is reserved for pregnant women and for use during pertussis outbreak responses.
Immunity to pertussis
An antibody level that is known to be protective against pertussis has not been demonstrated, so blood tests cannot be used to determine immunity .
Long-lasting immunity cannot be ensured after natural infection, so a history of infection is not specific enough for protection to be presumed .
Pertussis vaccination prevents severe disease; vaccinated individuals who do subsequently develop symptomatic disease are unlikely to be at risk of serious complications .
- World Health Organization. Pertussis vaccines: WHO position paper – August 2015. 90 (35), 433-460 [Accessed 25 October 2021]
- UK Health Security Agency (UKHSA) Immunisation against infectious disease – The Green Book. Department of Health. London. 7 April 2016. Chapter 24: Pertussis. [Accessed 14 December 2021]
- Public Health England. Vaccination of individuals with uncertain or incomplete immunisation status. Updated 21 August 2021 [Accessed 14 December 2021]
- Public Health England. Guidelines for the Public Health Management of Pertussis in England. Updated May 2021. [Accessed 14 December 2021]
- UK Health Security Agency (UKHSA). Guidance. Pertussis (whooping cough) vaccination programme for pregnant women: information for healthcare practitioners. Updated 6 September 2021. [Accessed 14 December 2021]
- Dabrera G, Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E et al. A Case Control Study to Estimate the Effectiveness of Maternal Pertussis Vaccination in Protecting Newborn Infants in England and Wales, 2012-2013. Clin Infect Dis. 19 October 2014; p333-337 [Accessed 14 December 2021]
- Amirthalingam G, Campbell H, Ribeiro S, Fry NK, Ramsay M, Miller E, Andrews N. Sustained Effectiveness of the Maternal Pertussis Immunization Program in England 3 Years Following Introduction. Clin Infect Dis. December 2016 [Supplement 4] S236-43 [Accessed 14 December 2021]
- Joint Committee on Vaccination and Immunisation. Minute of the meeting held 19 June 2019. [Accessed 14 December 2021]
- Donegan K, King B, Bryan P. Safety of pertussis vaccination in pregnant women in UK: observational study BMJ. 11 July 2014; 349:g4219. [Accessed 14 December 2021]
- World Health Organization. SAGE Pertussis Working Group. Background Paper. SAGE April 2014 [Accessed 14 December 2021]
- Kandeil W, van den Ende C, Bunge E M, Jenkins VA, Ceregido MA, Guignard A. A systematic review of the burden of pertussis disease in infants and the effectiveness of maternal immunization against pertussis, Expert Rev Vacccines, 19:7, 621-638, DOI: 10.1080/14760584.2020.1791092
- Edwards KM, Decker MD. Pertussis Vaccines In: Plotkin S, Orenstein W, Offit P Edwards KM (eds). Vaccines. 7th Edition. Elsevier 2018. 711-772.
- Campbell H, Amirthalingam G, Andrews N et al. Accelerating control of pertussis in England and Wales. Emerg Infect Dis [serial on the Internet]. January 2012. doi:10.3201/eid1801.110784 [Accessed 14 December 2021]
First Published : 14 Dec 2021
Last Updated :  21 Dec 2021