15 Jun 2017
Hepatitis A vaccine shortage: implications and advice for clinical practicePublic Health England and NaTHNaC offer guidance for health professionals during the current hepatitis A vaccine shortage
Following consultation with the Joint Committee of Vaccination and Immunisation, Public Health England and NaTHNaC offer the following temporary guidance for health professionals in the UK:
- Hepatitis A vaccine use should be prioritised; an effective risk assessment will ensure vaccine recommendations are appropriate, help identify higher risk travellers.
- For immunocompetent adults, and where adult monovalent vaccine is not available, a single priming dose of either paediatric monovalent hepatitis A vaccine or adult combination hepatitis A/B vaccine can be given (off-label)
- Non-immune HIV positive persons should preferentially receive standard adult antigen content monovalent HAV as a priming dose because of the poorer response rates to vaccine in this group.
- For adults primed with adult monovalent hepatitis A, a booster dose of either paediatric monovalent hepatitis A or adult combination hepatitis A/B vaccine can be given (off-label) where adult monovalent stock is not available.
- For adults primed with adult monovalent hepatitis A vaccine, a booster dose can be delayed until beyond the recommended 12 months, to five years, in most circumstances.
Health professionals are advised to follow recommendations as per the jurisdiction in which they practice. Further guidance will be published as information becomes available.