18 Dec 2018

Oral typhoid vaccine updated Summary of Product Characteristics (SPC)

Vivotif® SPC updated to provide three years protection and minimum age for vaccination reduced to five years Oral typhoid vaccine updated Summary of Product Characteristics (SPC)
The Summary of Product Characteristics (SPC) for oral typhoid vaccine, Vivotif® has been updated [1]. In line with Public Health England’s ‘Green Book’ Immunisation against infectious disease, the Vivotif® SPC now indicates revaccination at three years for travellers at continued risk [1,2]. Previously Vivotif’s licence covered one year of protection for travellers.
 
The updated Vivotif® SPC now indicates vaccination for adults and children aged five years and older [1]. Previously the marketing authority (licence) covered use in children from six years of age. Guidance on the use of Vivotif® in those aged five years is awaited from the Joint Committee on Vaccination and Immunisation.
 
Vivotif® vaccination is taken orally; the dose is one capsule taken on alternate days (three capsules in total). Each capsule should be taken with cold or lukewarm water (temperature not more than 37°C) on an empty stomach and at least one hour before the next meal [1]. Note that the vaccine capsule should not be chewed and should be swallowed whole as soon as possible after placing in the mouth [1]. This may be difficult for some young children.
 
Health professionals should ensure they are familiar with the Summary of Product Characteristics before prescribing the vaccine.

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